Phentolamine

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Trade Name

Regitine, Oraverse

Mechanism

Phentolamine is an alpha-adrenergic antagonist. It primarily works as a vasodilator through an alpha-1 receptor blockade. This vasodilation and eventual decrease in blood pressure is sensed by baroreceptors in the carotid sinus and aortic arch causes sympathetic stimulation and subsequent release of norepinephrine. This noepinephrine release stimulates the heart and causes increased HR and contractility to offset the drop in blood pressure.

Dosage

2.5 mg IV bolus, wait for response before further action

Indications

Hypertension on CPD, peripheral vascular spasms

Action

Peripheral vasodilator, cardiac stimulation

Site of Action

Alpha-adrenergic receptors

Adverse Effects

Orthostatic Hypotension

References

https://europepmc.org/article/med/949032 The Manual of Clinical Perfusion pg. 230