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Desmopressin is a synthetic antidiuretic hormone analog that has little vasoconstrictive effect. Instead, it may be used to maintain hemostasis by acting on endothelial cells to stimulate the release of von Willebrand factor (Factor VIII).
0.3 mcg/kg diluted in 50 mL of saline and given over 15 to 30 minutes
Diabetes Insipidus, improve coagulation due to a lack of factor VIII, hemophilia A
Site of action
Factor VIII storage sites in the plasma
https://www.nejm.org/doi/full/10.1056/nejm198605293142202?casa_token=9fzJn1Tk0XcAAAAA:zFavaHnseBQftMck7lWRtzb-wquqMAXNqAI2djt-SpQ0797qX8CkpZsARZAQW5syhsnUmtqDlao0nIQm Clinical Manual of Perfusion page 221