Dantrolene
Revision as of 00:46, 15 June 2021 by 70.187.25.179 (talk) (Created page with "==Trade Name== Dantrium ==Mechanism== Dantrolene inhibits ryanodine receptor calcium release channels that are expressed on the surface of sarcoplasmic reticulum. Inhibition...")
Trade Name
Dantrium
Mechanism
Dantrolene inhibits ryanodine receptor calcium release channels that are expressed on the surface of sarcoplasmic reticulum. Inhibition of these channels causes decreased calcium release and results in skeletal muscle relaxation.
Dose
1 mg/kg IV up to maximum dose of 10 mg/kg
Indications
Malignant hypothermia
Action
Reverses malignant hypothermia by relaxing skeletal muscle
Site of action
Skeletal muscle
Adverse Effects
Dizziness, lightheadedness, and drowsiness most common
References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702250/ https://www.sciencedirect.com/science/article/pii/S0021925820788265 Clinical Manual of Perfusion page 236