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Dantrolene inhibits ryanodine receptor calcium release channels that are expressed on the surface of sarcoplasmic reticulum. Inhibition of these channels causes decreased calcium release and results in skeletal muscle relaxation.
1 mg/kg IV up to maximum dose of 10 mg/kg
Reverses malignant hypothermia by relaxing skeletal muscle
Site of action
Dizziness, lightheadedness, and drowsiness most common
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702250/ https://www.sciencedirect.com/science/article/pii/S0021925820788265 Clinical Manual of Perfusion page 236