Amiodarone
Trade Name
Cordarone, Parcerone
Mechanism/Action
Class III Antiarrhythmic Drug
ECC Consideration
Metabolized and excreted via the liver, note decreased excretion in patients with liver deficiencies and during hypothermia.
Dose
Adults: ECC Doses
- Loading Dose: First 150mg over the first 10min (15mg/min)
- Following Dose: 360mg over the next 6 hours (1mg/min)
- Maintenance: 540 mg over the remaining 18 hours (.5mg/min)
Ventricular Arrhythmias
- IV: 15 mg/min for 10 min, then 1 mg/min for 6 hours, then maintain 0.5 mg/min continuous infusion.
- Supraventricular Arrhythmias: IV: 300 mg IV over 1 hour
Decrease in severe liver deficiency
Indications
Recurrent ventricular fibrillation or hemodynamically unstable ventricular tachycardia, supraventricular arrhythmias, atrial fibrillation
Adverse Effects
Alcoholism, arrhythmia exacerbation, AV block, bradycardia, cardiac arrhythmias, cardiac disease, coronary artery disease, diabetes mellitus, females, hypertension, hypocalcemia, long QT syndrome, malnutrition, myocardial infarction, QT prolongation, requires an experienced clinician, sick sinus syndrome
Contraindications
Sinus node dysfunction, 2nd or 3rd degree AV block, sinus bradycardia (without pacemaker), Iodine hypersensitivity, Cardiogenic shock, heart failure, hypotension, hypovolemia, ventricular dysfunction
References
https://www.nexterone.com/dosing.html
https://www.pdr.net/drug-summary/Cordarone-amiodarone-hydrochloride-997.5974