Albumin 5%

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Trade Name

Albumin (Human) 5% Solution, Albuked, Albumarc, Albuminar, Albuminex, AlbuRx, Albutein, Buminate, Flexbumin, Kedbumin, Macrotec, Plasbumin


Colloid Osmotic / Volume Expander


For Use During Cardiopulmonary Bypass Surgery - ECC Dosage

  • Adults
    • Adjust the albumin and crystalloid pump prime to achieve a hematocrit of 20% and a plasma albumin concentration of 2.5 g/100 mL in the patient. (PDR)
  • Infants, Children, and Adolescents
    • Albumin may be used in the priming fluid.

For Treatment of Shock Due to Hypovolemia

  • Dosage should be based on patient response.
  • Adult
    • initially, rapidly administer 5% solution IV. As the plasma volume approaches normal, infuse IV at a rate <= 2—4 mL/minute (rate of 25% solution <= 1 mL/minute). May repeat the initial dose in 15—30 minutes. Continued protein loss may require administration of whole blood and/or other blood factors.
  • Children
    • 0.5—1 g/kg/dose IV. May repeat as needed. The maximum dosage is 6 g/kg/day.
  • Neonates
    • The usual dose is 0.5 g/kg IV as a 5% solution; however, dosages may range from 0.25—0.5 g/kg IV. The 25% solution should be avoided in preterm neonates due to the risk of intraventricular hemorrhage.

Half Life



Plasma or Blood Volume Deficit (shock, burns, pancreatitis, postoperative albumin loss, hypoproteinemia with an oncotic deficit - aids with oncotic pressure). Colloid osmotic properties are the main reason for its clinical use.

ECC Considerations

The 5% concentration is isotonic and iso-oncotic with normal human plasma. The 25% concentration is approximately 5x the concentration of normal human plasma


Increases intravascular oncotic pressure, pulling fluids from the interstitial space to reduce edema and circulating blood volume.


  • ALbumin Hypersensitivity
  • Anemia, coagulopathy, electrolyte imbalance, esophageal varices, heart failure, hypertension, pulmonary edema, renal failure, surgery, trauma
  • Premature neonates, renal disease
  • Viral Infection
  • Dehydration
  • Pregnancy
  • Breas Feeding