Albumin 5%

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Trade Name

Albumin (Human) 5% Solution, Albuked, Albumarc, Albuminar, Albuminex, AlbuRx, Albutein, Buminate, Flexbumin, Kedbumin, Macrotec, Plasbumin

Mechanism

Colloid Osmotic / Volume Expander

Dosage

For Use During Cardiopulmonary Bypass Surgery - ECC Dosage

  • Adults
    • Adjust the albumin and crystalloid pump prime to achieve a hematocrit of 20% and a plasma albumin concentration of 2.5 g/100 mL in the patient. (PDR)
  • Infants, Children, and Adolescents
    • Albumin may be used in the priming fluid.

For Treatment of Shock Due to Hypovolemia

  • Dosage should be based on patient response.
  • Adult
    • initially, rapidly administer 5% solution IV. As the plasma volume approaches normal, infuse IV at a rate <= 2—4 mL/minute (rate of 25% solution <= 1 mL/minute). May repeat the initial dose in 15—30 minutes. Continued protein loss may require administration of whole blood and/or other blood factors.
  • Children
    • 0.5—1 g/kg/dose IV. May repeat as needed. The maximum dosage is 6 g/kg/day.
  • Neonates
    • The usual dose is 0.5 g/kg IV as a 5% solution; however, dosages may range from 0.25—0.5 g/kg IV. The 25% solution should be avoided in preterm neonates due to the risk of intraventricular hemorrhage.

Half Life

16-24hrs

Indications

Plasma or Blood Volume Deficit (shock, burns, pancreatitis, postoperative albumin loss, hypoproteinemia with an oncotic deficit - aids with oncotic pressure). Colloid osmotic properties are the main reason for its clinical use.

ECC Considerations

The 5% concentration is isotonic and iso-oncotic with normal human plasma. The 25% concentration is approximately 5x the concentration of normal human plasma


Action

Increases intravascular oncotic pressure, pulling fluids from the interstitial space to reduce edema and circulating blood volume.

Contraindications

  • ALbumin Hypersensitivity
  • Anemia, coagulopathy, electrolyte imbalance, esophageal varices, heart failure, hypertension, pulmonary edema, renal failure, surgery, trauma
  • Premature neonates, renal disease
  • Viral Infection
  • Dehydration
  • Pregnancy
  • Breas Feeding

References

https://www.pdr.net/drug-summary/Albuked-5-albumin--human--2970